Characteristics and outcomes of COVID-19 patients admitted in the medical ICU of a tertiary public hospital in the Philippines during the first two months of being a COVID-19 referral center

@#Introduction. The University of the Philippines-Philippine General Hospital (UP-PGH) began its operations as a COVID-19 referral center on March 30, 2020. Local studies reporting characteristics of patients in the intensive care units (ICUs) are lacking. Objectives. 1) To describe the baseline characteristics and outcomes of the initial cohort of COVID-19 patients in the medical ICU. 2) To report the initial situation and strategies in the ICU during the first two months of being a COVID-19 referral center. Methods. We conducted a review of records of all patients with confirmed COVID-19 admitted to the medical ICU of UP-PGH between April 1 to May 31, 2020. Patient demographics, comorbidities, APACHE-II score, signs and symptoms, laboratory and radiologic results, respiratory and vasopressor support, and outcomes were collected. Results. Out of 35 patients with confirmed COVID-19, majority were above 60 years old (63%). Hypertension was the most frequent comorbidity (77%). Fever was the most common symptom (51%). The mean duration of symptoms prior admission was 9 ± 7 days. Anemia and leukocytosis with neutrophilia was common. Lactate dehydrogenase (LDH) and high-sensitivity C-reactive protein (HSCRP) were elevated in most patients. Majority of patients (66%) had moderate level of hypoxemia on admission. Bilateral pneumonia on chest radiograph was found in 34 patients. Hydroxychloroquine and chloroquine were the most commonly used drugs. A total of 24 patients (69%) required invasive mechanical ventilation while 15 (43%) needed pressor support. Twenty-two expired (63%) while thirteen (37%) patients were discharged from the medical ICU. Conclusion. The clinical characteristics in our set of patients are consistent with other studies on critically ill patients. Mortality in the medical ICU was high.

Inhalation injury: A two-year pilot assessment on the adherence to the clinical pathway for adult burn patients at high risk for inhalation injury in the Philippine General Hospital

OBJECTIVE@#This study determined the mean overall adherence to the clinical pathway formulated by the Section of Pulmonology together with the Division of Burns for adult burn patients at high risk for inhalation injury admitted at the UP-PGH ATR Burn Center in a two-year period@*METHODOLOGY@#A retrospective cohort study regarding adherence to the clinical pathway of acutely burned adult patients at high risk for inhalation injury admitted at the UP-PGH ATR Burn Center between August 2016 to July 2018 was conducted. Medical records were reviewed and an adherence checklist was used to assess each item in the clinical pathway. For the adherence and patient profile, descriptive statistics were used.@*RESULTS@#This pilot assessment study showed acceptable rates of adherence and implementation of the clinical pathway. Overall, 60% of the cases followed the clinical pathway completely. While 26.67% had acceptable rates of compliance (more than half of items adhered), while 13% of the cases scored adhered to less than half of the items.@*CONCLUSION@#The pathway has been shown to be a feasible clinical pathway that can be implemented in a tertiary hospital setting.

Balanced Crystalloids versus Normal Saline as Intravenous Fluid Therapy among Critically Ill patients: A meta-analysis of randomized controlled trials

Introduction@#Recent studies on critically ill adults has shown that use of normal saline with its supraphysiologic chloride content has been associated with an increased incidence of hyperchloremic metabolic acidosis, acute kidney injury (AKI), renal replacement therapy (RRT), hypotension and death. The objective of this meta-analysis was to assess the clinical outcomes associated with the use of balanced crystalloids versus normal saline solution.@*Methods@#We searched PubMed/MEDLINE, Embase and Cochrane Library (CENTRAL) databases in accordance with PRISMA guidelines. Our inclusion criteria were the following: randomized controlled trials, adult critically ill patients, comparisons between patients receiving either balanced crystalloids (lactated ringer’s solution, plasma-lyte) or normal saline, and at least one endpoint that measure intensive care unit mortality, risk of AKI (defined as stage 2 or greater in the RIFLE criteria) and risk of RRT. Risk ratios (RRs) and confidence intervals (C.I) were calculated via Review Manager Version 5.3 using the fixed-effect modelling.@*Results@#A total of four randomized controlled trials, which were all assessed to be good quality and low risk of bias, with 19,105 patients were included. Use of balanced crystalloids showed a trend towards lower incidence of AKI (RR 0.94, 95% C.I [0.87-1.02], P=0.69), RRT use (RR 0.91, 95% C.I. [0.771.07], P=0.29) and ICU mortality (RR 0.91, 95% C.I. [0.82-1.01], P=0.95). There is no significant heterogeneity identified.@*Conclusion@#Use of balanced crystalloids as intravenous fluid therapy among critically ill patients demonstrated a trend toward lower incidence of AKI, RRT and ICU mortality, compared to normal saline solution.